I look at the data from a different angle. How much MSM coverage is it getting, and what is the current narrative.
When 95% of cases are historical, one immediately is suspicious. Data has been vague with a lot of hand waving.
UKHSA already back peddling the narrative just like CDC did recently. It is stated public policy to get child vaccine rates up. This is nothing more than nudge team propaganda, just like MIS-C and POTS-C before it 💰🤦♀️
I appreciate your taking the time to reply: I take it that the short answers are no and no. I agree that the epidemiology is not clearly supportive of any extant hypothesis of which I am aware, and regardless would lean more in favor of a role for adenoviral vector DNA rather than the mRNA vaccines, the former being widely used in the UK where the first and densest case clusters seem to have arisen. The Hoskins effect with subsequent human adenovirus exposure merely requires a prior first infection event with an immunologically related virus: it's unclear, to me at least, whether a chimpanzee adenovirus qualifies for that description. I perceive that a discounting based on "biological implausibility" is another form of the confirmation bias you rightly decry. In any event, for what is still a rare phenomenon, it's likely that a "perfect storm" of confluent factors is required to produce a clinically recognizable event, so the widest possible net of scrutiny deserves to be applied to identify a pattern linking these cases. I'm afraid that the world is in for some giant "hoocoodanode?" moments regarding some "implausible" consequences to our mass COVID-19 vaccinations, although certainly the particular hypotheses I floated may be proven invalid, should anyone care to investigate.
Steroid responsive acute hepatitis without demonstrable virions is suggestive of an autoimmune etiology. To your knowedge, has anyone considered the possibility that the recently documented shedding of mRNA-containing exomes by COVID-19 vacine recipients may have led to ingestion of same by close contacts, with resulting uptake by their livers, and, given that vaccine mRNA has been demonstrated to persist in reticuloendothelial system loci for at least 60 days post administration, a subsequent anamnestic immune response to mRNA-induced ongoing spike protein synthesis in hepatocytes then being triggered by infection with wild SARS CoV2 virus? Equally intriguing is the possibility that adenoviral vector COVID-19 vaccine virions, if shed by recipients, could by the same mechanism be accompanied by low level expression of combined adenoviral and spike protein in hepatocytes, and a Hoskin effect triggered by exposure to wild adenovirus could result in concurrent production of antibodies to both the SARS-CoV2 spike and the vector adenoviral viral proteins being synthesized, causing manifestations of apparent acute "autoimmunity." This hypothesis has the advantage of accounting for the frequent association of adenovirus in these clusters of acute pediatric hepatitis, the predominance of cases in infants and preschoolers, possibly kept adenovirus naive by prior pandemic "lockdown" precautions, and the apparent lack of cases in 2020, when there were widespread SARS-CoV2 infections, but only few available COVID-19 vaccinations prior to their aggressive rollout in 2021. All of these possibilities can be further supported or refuted by some simple clipboard epidemiology, if the appropriate questions are asked regarding COVID-19 vaccination history (type and timing) of close contacts, (and maybe breastfeeding history for infants). Do you know if these questions have been addressed systematically to date, or whether anyone can be induced to pursue them? Confirmation bias is indeed our enemy in solving such puzzles!
Excellent summary. Thank you.
Good analysis.
I look at the data from a different angle. How much MSM coverage is it getting, and what is the current narrative.
When 95% of cases are historical, one immediately is suspicious. Data has been vague with a lot of hand waving.
UKHSA already back peddling the narrative just like CDC did recently. It is stated public policy to get child vaccine rates up. This is nothing more than nudge team propaganda, just like MIS-C and POTS-C before it 💰🤦♀️
I appreciate your taking the time to reply: I take it that the short answers are no and no. I agree that the epidemiology is not clearly supportive of any extant hypothesis of which I am aware, and regardless would lean more in favor of a role for adenoviral vector DNA rather than the mRNA vaccines, the former being widely used in the UK where the first and densest case clusters seem to have arisen. The Hoskins effect with subsequent human adenovirus exposure merely requires a prior first infection event with an immunologically related virus: it's unclear, to me at least, whether a chimpanzee adenovirus qualifies for that description. I perceive that a discounting based on "biological implausibility" is another form of the confirmation bias you rightly decry. In any event, for what is still a rare phenomenon, it's likely that a "perfect storm" of confluent factors is required to produce a clinically recognizable event, so the widest possible net of scrutiny deserves to be applied to identify a pattern linking these cases. I'm afraid that the world is in for some giant "hoocoodanode?" moments regarding some "implausible" consequences to our mass COVID-19 vaccinations, although certainly the particular hypotheses I floated may be proven invalid, should anyone care to investigate.
Steroid responsive acute hepatitis without demonstrable virions is suggestive of an autoimmune etiology. To your knowedge, has anyone considered the possibility that the recently documented shedding of mRNA-containing exomes by COVID-19 vacine recipients may have led to ingestion of same by close contacts, with resulting uptake by their livers, and, given that vaccine mRNA has been demonstrated to persist in reticuloendothelial system loci for at least 60 days post administration, a subsequent anamnestic immune response to mRNA-induced ongoing spike protein synthesis in hepatocytes then being triggered by infection with wild SARS CoV2 virus? Equally intriguing is the possibility that adenoviral vector COVID-19 vaccine virions, if shed by recipients, could by the same mechanism be accompanied by low level expression of combined adenoviral and spike protein in hepatocytes, and a Hoskin effect triggered by exposure to wild adenovirus could result in concurrent production of antibodies to both the SARS-CoV2 spike and the vector adenoviral viral proteins being synthesized, causing manifestations of apparent acute "autoimmunity." This hypothesis has the advantage of accounting for the frequent association of adenovirus in these clusters of acute pediatric hepatitis, the predominance of cases in infants and preschoolers, possibly kept adenovirus naive by prior pandemic "lockdown" precautions, and the apparent lack of cases in 2020, when there were widespread SARS-CoV2 infections, but only few available COVID-19 vaccinations prior to their aggressive rollout in 2021. All of these possibilities can be further supported or refuted by some simple clipboard epidemiology, if the appropriate questions are asked regarding COVID-19 vaccination history (type and timing) of close contacts, (and maybe breastfeeding history for infants). Do you know if these questions have been addressed systematically to date, or whether anyone can be induced to pursue them? Confirmation bias is indeed our enemy in solving such puzzles!