Thanks for this summary. Why do Hepatitis vaccines not work to prevent this? (Wondering for my own kids who have autoimmune genetics but are vaxxed against Hepatitis, at least the ones recommended in the US)
Excellent summary, as usual. It's interesting to tie this in to the use of AAV in gene therapy. The virologist seem to have improved the engineering of AAV significantly, but as I recall the risk of hepatitis from AAV-vectorized gene therapies has been a significant barrier in the past. I wonder if the connection with the HLA variant was known before, and if it may pave the way for better patient selection for some of these (potentially life-changing) gene therapies?
WELL DONE AS ALWAYS ALLY
Thanks for this summary. Why do Hepatitis vaccines not work to prevent this? (Wondering for my own kids who have autoimmune genetics but are vaxxed against Hepatitis, at least the ones recommended in the US)
Excellent summary, as usual. It's interesting to tie this in to the use of AAV in gene therapy. The virologist seem to have improved the engineering of AAV significantly, but as I recall the risk of hepatitis from AAV-vectorized gene therapies has been a significant barrier in the past. I wonder if the connection with the HLA variant was known before, and if it may pave the way for better patient selection for some of these (potentially life-changing) gene therapies?
TXS